Which of the following amino acid substitution is responsible for causing sickle cell anemia

Question. Which of the following amino acid substitution is responsible for causing sickle cell anemia?
A. Valine is substituted by Glutamic acid in the α globin chain at the sixth position
B. Valine is substituted by Glutamic acid in the β globin chain at seventh position
C. Glutamic acid is substituted by Valine in the α globin chain at the sixth position
D. Glutamic acid is substituted by Valine in the β globin chain at the sixth position

Answer: D. Glutamic acid is substituted by Valine in the β globin chain at the sixth position

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